- KYPROLIS® (carfilzomib) is indicated in combination with dexamethasone, or with lenalidomide plus dexamethasone, or with daratumumab plus dexamethasone, ... Read More Close
*A treatment that is accepted by medical experts as a proper treatment for a certain type of disease and that is widely used by healthcare professionals. Also called best practice, standard medical care, and standard therapy.1
†The primary endpoint was PFS. Patients included in these clinical trials had 1-3 prior lines of therapy.3-6
Learn about your peers’ experience treating RRMM patients with KYPROLIS®
Dr. Jennifer Caudle with Dr. Joseph Mikhael
“While the majority of patients with multiple myeloma receive an immunomodulatory agent, or IMiD, as part of their initial treatment, there’s been growing interest in what their next treatment should be if they don’t respond or become refractory to IMiDs. But with the approval of a regimen based on the CANDOR study results, these patients now have an IMiD-free option. What that regimen is, and the key findings that came out of the CANDOR study are what we’ll be focusing on today.”
“You need two reasons to prescribe. Efficacy and safety. KYPROLIS® combinations have consistently demonstrated improvement in progression-free survival vs comparators across four phase 3 clinical trials.* ”
~ Ariel F. Grajales-Cruz, MD
*Kd vs Vd, KRd vs Rd, DKd vs Kd, Isa-Kd vs Kd.
NCCN, National Comprehensive Cancer Network® (NCCN®); PFS, progression-free survival; RRMM, relapsed or refractory multiple myeloma.
Please see accompanying full Prescribing Information.
Please see accompanying full Prescribing Information.
References: 1. NCI Dictionary of Cancer terms. Comprehensive Cancer Information - NCI. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/standard-of-care. Accessed February 1, 2025. 2. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Multiple Myeloma V.1.2025. © National Comprehensive Cancer Network, Inc. 2024. All rights reserved. Accessed November 20, 2024. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way. 3. Usmani SZ, Quach H, Mateos MV, et al. Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): updated outcomes from a randomised, multicentre, open-label, phase 3 study. Lancet Oncol. 2022;23(1):65-76. 4. Martin T, Dimopoulos MA, Mikhael J, et al. Isatuximab, carfilzomib, and dexamethasone in patients with relapsed multiple myeloma: updated results from IKEMA, a randomized Phase 3 study. Blood Cancer J. 2023;13:1-12. 5. Stewart AK, Rajkumar SV, Dimopoulos MA, et al. Carfilzomib, lenalidomide, and dexamethasone for relapsed multiple myeloma. N Engl J Med. 2015;372:142-152. 6. Dimopoulos MA, Moreau P, Palumbo A, et al. Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study. Lancet Oncol. 2016;17:27-38. 7. KYPROLIS® (carfilzomib) prescribing information, Onyx Pharmaceuticals Inc., an Amgen Inc. subsidiary. 8. Data on file [1], Amgen; 2024. 9. Usmani SZ, Quach H, Mateos MV, et al. Final analysis of carfilzomib, dexamethasone, and daratumumab vs carfilzomib and dexamethasone in the CANDOR study. Blood Advances. 2023;7:3739-3748. 10. Siegel DS, Dimopoulos MA, Ludwig H, et al. Improvement in overall survival with carfilzomib, lenalidomide, and dexamethasone in patients with relapsed or refractory multiple myeloma. J Clin Oncol. 2018;36:728-734. 11. SARCLISA® (isatuximab-irfc) prescribing information. Bridgewater, NJ: sanofi-aventis U.S. LLC.